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Clinicaltrials.gov was looked for registered analyze protocols. The keywords and phrases “palmitoylethanolamide” and “ache” resulted in thirteen entries, of which 3 were being concluded. None of them fulfilled our eligibility conditions.Knowledge of exogenous PEA pharmacokinetics is still at an early stage [212]. Upcoming exploration should
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Of Notice is the fact that, because of PEA’s large lipophilicity, micronized or extremely-micronized formulations are believed to generally be more very easily absorbable, with additional favorable pharmacokinetics and larger efficacy. Despite the fact that There exists some proof supporting this principle, there continues to be no proof on the s